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    通过何种机制成皮肤损伤的，目前在理论上认为UVA和UVB照射后可产生高度反应的自由基，这些自由基过氧化或交联作用，使DNA受到损伤，同时与蛋白质、脂类及辅酶起反应，造成DNA复制错误细胞膜受损，及一些细胞酶类受到破坏，并且UVA和UVB可诱导抗原刺激反应的抑制途径，使皮肤的免疫功能受到抑制。上述各种因素的综合作用导致了皮肤内各种细胞的损伤、突变和恶性转化。真皮上部侵润的炎症细胞可份泌弹性纤维酶及胶原酶，同时损伤表皮细胞可释放细胞因子及花生四烯酸的代谢产物，造成了真皮层中胶原蛋白的降解及弹力纤维的变性。慢性UVA和UVB辐射对人类表皮的黑素细胞具有增值活化作用，在暴露部位表皮的黑素细胞密度是非暴露部位的2倍，同时紫外线是黑素细胞的多巴胺反应增强，使得暴露部位皮肤表现为色素沉着过度。

　

　

紫外线
光对皮规的损害
老化皮肤的组织变化
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