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1、深信自己是真实的异性，终身感受是异性中的一员。

2、声称自己是异性，躯体发育并非异性，更非两性畸形。

3、深恶痛绝自身的生理特征和生殖系统的迹象，如乳房、月经、阴茎、睾丸等。

4、强烈要求医学改变躯体而成为自己认为应该的属性。

5、着同性装束感觉痛苦，着异性装束感到满足。

6、恼恨别人把自己看成现有属性，对理解自己是异性感到宽慰。

7、对同性可产生同性异性恋，而确认自己应该是异性。

8、要求变性不是单独追求性行为，亦非对异性性别的偏爱。